ASTUTE: Association of SomaTic mUtaTions to gene Expression profiles

Branch	Status
master
development

ASTUTE is an R package designed to integrate cancer genomic and transcriptomic data in order to perform genotype-phenotype mapping. It leverages regularized regression with LASSO penalty to uncover associations between somatic mutations and gene expression profiles.

Table of Contents

• Features
• Installation
• Contact

Features

• Genotype-Phenotype Mapping: Perform sophisticated analyses to uncover the relationship between somatic mutations and gene expression profiles.
• Regularized Regression: Employ LASSO penalty to prevent overfitting and select significant features.
• Bootstrapping: Calculate p-values and confidence intervals for expression changes.
• Patient Stratification: Identify and utilize expression signatures for prognosis and therapeutic decision-making.

Installation

You can install the development version of ASTUTE from GitHub using the devtools package:

# Install devtools if you haven't already
install.packages("devtools")
library("devtools")

# Install ASTUTE from GitHub
devtools::install_github("ramazzottilab/ASTUTE")

Contact

Please feel free to contact us if you have any questions regarding our tool at daniele.ramazzotti@unimib.it.